A normal working neurotransmitter will be working perfectly fine before you even ingest cocaine. A normal pathway should usually be going through the following path, dopamine is released into the synapse, a small gap in the between two different neurons, the dopamine then binds to proteins called dopamine receptors on the other neuron. Another protein called a transporter then removes the dopamine from the neuron and synapse and takes it for further use later. When cocaine is ingested, it binds to the dopamine transporter blocking the removal of dopamine from the synapse leaving it all there causing the euphoria that one would experience from taking this drug. In people that are addicted to cocaine, the brain relies on this drug to keep up the high degree of pleasure with some elevated levels of some the neurotransmitter in the reward circuits. There can even be some new neurotransmitters created after a postsynaptic membrane adapts to the high dopamine levels. This results in depression and more cravings of cocaine. Cocaine can affect everybody, from rich people to the homeless person who may live down the street. On average, there are about 15,000 Americans who die every year from cocaine use. In 2014, there were an estimated 1.5 million current cocaine users aged 12 or older. Over 800,000 Americans said that they had an addiction to cocaine in 2011. This number is most likely a lot higher now than it was back then. The United States have been trying to control sales of drugs for decades. We have increased our budget dramatically over the last twenty years. The Harrison Narcotics Act was the United States’ first federal drug policy. The act was passed in 194. It restricted the manufacture and sale of many different drugs such as cocaine, marijuana, heroin and morphine. The act was enforced harshly. Physicians, who were prescribing drugs to addicts on some different programs were harshly punished. The Drug Enforcement Agency initiated a new mission, Operation Intercept, which pressured Mexico to regulate its marijuana growers. Trade came to a virtual standstill between the two countries. After all of this, the US is still trying to stop all drug sales from happening in the country. Cocaine is a really addictive drug that affects many people around the world. There is a lot that will go down inside the brain after cocaine is taken. It will block transporters in the dopamine neurotransmitters and will increase the serotonin levels inside of the brain. This will give the body the effects that normally happen when cocaine is taken.